International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 289)

CAS No.: 215-58-7
Chem. Abstr. Name: Benzo(b)triphenylene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Dibenz[a,c]anthracene was tested for carcinogenicity in one experiment by skin application to female mice and produced skin tumours. It was also tested in three experiments using the mouse-skin intiation-promotion assay and showed initiating activity.

No data on the teratogenicity of this chemical were available.

In the presence of an exogenous metabolic system, dibenz[a,c]anthracene was mutagenic to Salmonella typhimurium and mammalian cells in culture. It was positive in an assay for differential survival, using DNA repair-proficient/-deficient strains of Bacillus subtilis, and induced unscheduled DNA repair synthesis in cultured mammalian cells. In two of three studies it induced morphological transformation in mammalian cells.

There is sufficient evidence that dibenz[a,c]anthracene is active in short-term tests.

5.2 Human data

Dibenz[a,c]anthracene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to dibenz[a,c]anthracene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

There is limited evidence that dibenz[a,c]anthracene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)


Last updated: 17 April 1998

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