International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 309)

CAS No.: 224-41-9
Chem. Abstr. Name: Dibenz(a,j)anthracene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Dibenz[a,j]anthracene was tested for carcinogenicity in female mice by skin application and produced skin tumours. It was also tested in mice by subcutaneous injection and produced a few tumours at the site of injection.

No data were available on the teratogenicity of this compound.

In the one available study, dibenz[a,j]anthracene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that dibenz[a,j]anthracene is active in short-term tests.

5.2 Human data

Dibenz[a,j]anthracene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to dibenz[a,j]anthracene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

N.B. - Studies on occupational exposure to polynuclear aromatic compounds will be considered in future IARC Monographs.

5.3 Evaluation

There is limited evidence that dibenz[a,j]anthracene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)


Last updated: 17 April 1998

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       Toxicological Abbreviations