International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 321)

CAS No.: 5385-75-1
Chem. Abstr. Name: Dibenz(a,e)aceanthrylene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Dibenzo[a,e]fluoranthene was tested for carcinogenicity in one study by skin application to mice and produced skin tumours. It was also tested in the mouse-skin initiation-promotion assay and was active as an initiator.

Dibenzo[a,e]fluoranthene was tested in mice by subcutaneous administration and produced sarcomas at the injection site.

No data on the teratogenicity of this chemical were available.

No data were available to evaluate the activity of dibenzo[a,e]fluoranthene in short-term tests.

5.2 Human data

Dibenzo[a,e]fluoranthene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to dibenzo[a,e]fluoranthene occurs primarily through the smoking of tobacco; it may also occur through inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

There is limited evidence that dibenzo[a,e]fluoranthene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)


Last updated: 17 April 1998

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