International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 365)

CAS No.: 86-73-7

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Fluorene was tested for carcinogenicity in mice by skin application and by subcutaneous administration and in female rats by oral administration in the diet. The studies were considered inadequate for evaluation.

No data were available on the teratogenicity of fluorene.

Fluorene was not mutagenic to Salmonella typhimurium. In the one available study, it did not induce unscheduled DNA synthesis in primary rat hepatocyte cultures.

There is inadequate evidence that fluorene is active in short-term tests.

5.2 Human data

Fluorene is present as a major component of the total content of polynuclear aromatic compounds in the environment. Human exposure to fluorene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

The available data are inadequate to permit an evaluation of the carcinogenicity of fluorene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 63: Group 3)


Last updated: 17 April 1998

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