International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 373)

CAS No.: 193-39-5
Chem. Abstr. Name: Indeno(1,2,3-cd)pyrene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Indeno[l,2,3-cd]pyrene has been shown to be carcinogenic to experimental animals (see 'General Remarks on the Substances Considered', in this volume and IARC, 1973).

No data on the teratogenicity of this compound were available.

Indeno[l,2,3-cd]pyrene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that indeno[1,2,3-cd]pyrene is active in short-term tests.

5.2 Human data

Indeno[1,2,3-cd]pyrene is present as a component of the polynuclear aromatic compound content in the environment. Human exposure to indeno[1,2,3-cd]pyrene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

There is sufficient evidence that indeno[1,2,3-cd]pyrene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 3 (1973)

Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 2B)


Last updated: 18 April 1998

    See Also:
       Toxicological Abbreviations