International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 447)

CAS No.: 217-59-4

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Triphenylene was tested for carcinogenicity in one study by skin application to male mice. No increase in the incidence of skin tumours was observed.

No data on the teratogenicity of this compound were available.

Triphenylene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that triphenylene is active in short-term tests.

5.2 Human data

Triphenylene is present as a major component of the total content of polynuclear aromatic compounds in the environment. Human exposure to triphenylene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

The available data are inadequate to permit an evaluation of the carcinogenicity of triphenylene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 3)


Last updated: 17 April 1998

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