International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 33 (1984) (p. 201)

CAS No.: 892-21-7
Chem. Abstr. Name: Fluoranthene, 3-nitro-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

In one limited experiment in which 3-nitrofluoranthene was tested in male rats by subcutaneous injection, sarcomas were observed at the injection site.

3-Nitrofluoranthene was mutagenic to Salmonella typhimurium in the presence and absence of an exogenous metabolic system. It induced morphological transformation in Syrian hamster embryo cells.

5.2 Human data

Environmental exposure to 3-nitrofluoranthene occurs, as it is a constituent of particulate matter in diesel-engine exhaust and in urban air. It is not produced commercially.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

The available data are inadequate to permit an evaluation of the carcinogenicity of 3-nitrofluoranthene to experimental animals.

No data on humans were available.

No evaluation of the carcinogenicity of 3-nitrofluoranthene to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)


Last updated: 20 April 1998

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