Allyl Isovalerate (IARC Summary & Evaluation, Volume 36, 1985)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

ALLYL ISOVALERATE

VOL.: 36 (1985) (p. 69)

CAS No.: 2835-39-4
Chem. Abstr. Name: Butanoic acid, 3-methyl-, 2-propenyl ester

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Allyl isovalerate has been used since the 1950s as a fragrance raw material in cosmetics, lotions and perfumes and in certain food products, although it is not known whether it is used in these applications currently.

5.2 Experimental data

Allyl isovalerate was tested for carcinogenicity by intragastric intubation in mice of one strain and in rats of one strain. In mice, it induced papillomas of the forestomach in males and increased the incidence of lymphomas in females. In rats an increased incidence of mononuclear-cell leukaemia was observed in animals of both sexes.

Allyl isovalerate was not mutagenic to bacteria.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of allyl isovalerate to humans was available to the Working Group.

5.4 Evaluation

There is limited evidence for the carcinogenicity of allyl isovalerate to experimental animals.

In the absence of epidemiological data, no evaluation could be made of the carcinogenicity of allyl isovalerate to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonyms

Allyl isovalerianate
Allyl 3-methylbutyrate
FEMA No. 2045
Isovaleric acid, allyl ester
3-Methylbutanoic acid, 2-propenyl ester
3-Methylbutyric acid, allyl ester
2-Propenyl isovalerate
2-Propenyl 3-methylbutanoate

Last updated: 13 April 1999





























    See Also:
       Toxicological Abbreviations
       ALLYL ISOVALERATE (JECFA Evaluation)
       Allyl Isovalerate  (IARC Summary & Evaluation, Volume 71, 1999)