International Agency for Research on Cancer (IARC) - Summaries & Evaluations
DIGLYCIDYL RESORCINOL ETHER
VOL.: 36 (1985) (p. 181)
CAS No.: 101-90-6
Chem. Abstr. Name: Oxirane, 2,2'-[1,3-phenylenebis(oxymethylene)]bis-
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Diglycidyl resorcinol ether has been produced since at least 1974.
It has only limited application, principally in the aerospace
industry.
5.2 Experimental data
Diglycidyl resorcinol ether (of technical grade) was tested for
carcinogenicity by intragastric intubation in mice of one strain and
in rats of one strain. It induced squamous-cell carcinomas and
papillomas of the forestomach in animals of both species. In female
mice, an increased incidence of hepatocellular tumours was observed.
In one experiment in mice, no skin tumour was observed after skin
application.
Diglycidyl resorcinol ether (of technical grade) was mutagenic to
bacteria.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
diglycidyl resorcinol ether to humans was available to the Working
Group.
5.4 Evaluation
There is sufficient evidence for the carcinogenicity of a
technical grade of diglycidyl resorcinol ether to experimental
animals.
No data on the carcinogenicity of diglycidyl resorcinol ether to
humans were available to the Working Group.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 11 (1976)
Subsequent evaluation: Vol. 71 (1999)
Synonyms
- Araldite ERE 1359
- 1,3-Bis(2,3-epoxypropoxy)benzene
- meta-Bis(glycidyloxy)benzene
- Diglycidyl ether of resorcinol
- 1,3-Diglycidyloxybenzene
- Diglycidyl resorcinol
- NCI-C54966
- 2,2'-[1,3-Phenylenebis(oxymethylene)]bisoxirane
- RDGE
- Resorcinol bis(2,3-epoxypropyl)ether
- Resorcinol diglycidyl ether
- Resorcinol glycidyl ether
- Resorcinyl diglycidyl ether
Last updated: 13 April 1999