International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 36 (1985) (p. 315)
CAS No.: 105-74-8
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Lauroyl peroxide was first produced commercially in about 1941.
It is used principally in the production of polymers; small amounts
are employed in food packaging.
5.2 Experimental data
Lauroyl peroxide was tested by subcutaneous administration in mice
and rats and by skin application in mice. In one study in mice by
subcutaneous administration, the evidence concerning a carcinogenic
effect was inconclusive; in two other studies, no increase in tumour
incidence was observed. Two studies in mice by skin application were
inadequate for an evaluation of complete carcinogenicity; one study
indicated that lauroyl peroxide has promoting activity in mouse skin.
The available data are inadequate to evaluate the teratogenic
potential of lauroyl peroxide in mammals.
The available data are inadequate to evaluate the activity in
short-term tests of lauroyl peroxide.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
lauroyl peroxide to humans was available to the Working Group.
There is inadequate evidence for the carcinogenicity of lauroyl
peroxide to experimental animals.
In the absence of epidemiological data, no evaluation could be
made of the carcinogenicity of lauroyl peroxide to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
- Alperox C, C/S,F and S-35
- Dilauroyl peroxide
- Dodecanoyl peroxide
- Laurox Q and W40
- LYP 97 and 97F
Last updated: 13 April 1999