International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 37 (1985) (p. 225)

CAS Nos: 37620-20-5; 1133-64-8; 84237-39-8
Chem. Abstr. Name: Pyridine, 3-(1-nitroso-2-piperidinyl)-; pyridine, 3-(1-nitroso-2-piperidinyl)-,(S)-; pyridine, 3-(1-nitroso-2-piperidinyl), (+,-)-

5. Summary of Data Reported and Evaluation

5.1 Exposures

N'-Nitrosoanabasine (NAB) has been found in tobacco products (chewing tobacco and snuff) and in mainstream smoke from cigarettes. Thus, there is widespread exposure to NAB among users of tobacco products.

5.2 Experimental data

NAB was tested for carcinogenicity by oral administration in two strains of rats and by subcutaneous injection in hamsters. In rats, it induced oesophageal carcinomas and/or papillomas. The study in hamsters was inadequate for evaluation.

No data were available on mutagenic or related effects of NAB.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of NAB to humans was available to the Working Group.

5.4 Evaluation

There is limited evidence for the carcinogenicity of N'-nitrosoanabasine to experimental animals.

No data on humans were available.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)


Last updated: 21 April 1998

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