International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 37 (1985) (p. 233)

CAS No.: 71267-22-6
Chem. Abstr. Name: 2,3'-Bipyridine, 1,2,3,6-tetrahydro-1-nitroso-

5. Summary of Data Reported and Evaluation

5.1 Exposures

N'-Nitrosoanatabine (NAT) has been found in a variety of tobacco products (snuff, chewing tobacco, cigarettes and cigars), in mainstream and sidestream smoke from cigars and cigarettes, in saliva of chewers of betel quid with tobacco and in saliva of users of chewing tobacco and oral snuff. Some of the NAT in saliva appears to be formed endogenously from nitrite in saliva and tobacco alkaloids. Thus, there is widespread exposure to NAT among users of tobacco products and those exposed to sidestream smoke.

5.2 Experimental data

NAT was tested for carcinogenicity by subcutaneous injection in rats of one strain at three dose levels. There was no increase in tumour incidence.

No data were available on mutagenic or related effects of NAT.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of NAT was available to the Working Group.

5.4 Evaluation

The available data are inadequate to evaluate the carcinogenicity of N'-nitrosoanatabine to experimental animals.

No data on humans were available.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)


Last updated: 21 April 1998

    See Also:
       Toxicological Abbreviations