International Agency for Research on Cancer (IARC) - Summaries & Evaluations
4,4'-METHYLENEDIANILINE AND ITS DIHYDROCHLORIDE
VOL.: 39 (1986) (p. 347)
CAS No.: 101-77-9
Chem. Abstr. Name: Benzenamine, 4,4'-methylenebis-
CAS No.: 13552-44-8
Chem. Abstr. Name: Benzenamine, 4,4'-methylenebis-, dihydrochloride
5. Summary of Data Reported and Evaluation
5.1 Exposure data
4,4'-Methylenedianiline has been available commercially since the
1920s. It is used mainly as an intermediate in 4,4'-methylenediphenyl
diisocyanate production and as a curing agent for epoxy resins.
Exposure occurs during the production of 4,4'-methylenedianiline and
the use of 4,4'-methylenediphenyl diisocyanate resins.
5.2 Experimental data
4,4'-Methylenedianiline and its dihydrochloride were tested for
carcinogenicity by oral administration in mice, rats and dogs.
Treatment-related increases in the incidences of thyroid
follicular-cell adenomas and hepatocellular neoplasms were observed in
both male and female mice. In rats, treatment-related increases in
the incidences of thyroid follicular-cell carcinomas and hepatic
nodules were observed in males and thyroid follicular-cell adenomas
occurred in females. In a study in rats in which
4,4'-methylenedianiline was administered orally in conjunction with a
known carcinogen, the incidence of thyroid tumours was greater than
that produced by the carcinogen alone.
The available data were inadequate to evaluate the reproductive
effects or prenatal toxicity of 4,4'-methylenedianiline to
4,4'-Methylenedianiline was mutagenic to Salmonella typhimurium
in the presence of an exogenous metabolic system. It induced DNA
damage in Chinese hamster V79 cells in the presence of an exogenous
metabolic system, and induced DNA damage in the liver of rats and
sister chromatid exchange in the bone marrow of mice treated in vivo.
5.3 Human data
4,4'-Methylenedianiline is hepatotoxic. No data were available
to evaluate the reproductive effects or prenatal toxicity of
4,4'-methylenedianiline to humans.
No case report or epidemiological study was available to evaluate
the carcinogenicity of 4,4'-methylenedianiline to humans.
There is sufficient evidence for the carcinogenicity of
4,4'-methylenedianiline and its dihydrochloride to experimental
No data on humans were available.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 4 (1974)
Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 2B)
- Ancamine TL
- Araldite Hardener 972
- Epicure DDM
- Epikure DDM
- Jeffamine AP-20
- Methylenedianiline (VAN)
- Sumicure M
- para,para'-Methylenedianiline dihydrochloride
Last updated: 21 April 1998