International Agency for Research on Cancer (IARC) - Summaries & Evaluations
2,6-DICHLORO-para-PHENYLENEDIAMINE
VOL.: 39 (1986) (p. 325)
CAS No.: 609-20-1
Chem. Abstr. Name: 1,4-Benzenediamine, 2,6-dichloro-
5. Summary of Data Reported and Evaluation
5.1 Exposure data
2,6-Dichloro-para-phenylenediamine has been used to a limited
extent as an intermediate in dye and resin manufacture. The main
potential for exposure derives from its formation as a metabolite of
the pesticide 2,6-dichloro-4-nitroaniline.
4.2 Experimental data
2,6-Dichloro-para-phenylenediamine was tested in mice and rats by
oral administration in the diet. Increased numbers of liver-cell
tumours were observed in mice; no treatment-related tumour was found
in rats.
No data were available to evaluate the reproductive effects or
prenatal toxicity of 2,6-dichloro-para-phenylenediamine to
experimental animals.
2,6-Dichloro-para-phenylenediamine was mutagenic to Salmonella
typhimurium in the presence and absence of an exogenous metabolic
system.
4.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of 2,6-dichloro-para-phenylenediamine to humans.
No case report or epidemiological study was available to evaluate
the carcinogenicity of 2,6-dichloro-para-phenylenediamine to humans.
4.4 Evaluation
There is limited evidence for the carcinogenicity of
2,6-dichloro-para-phenylenediamine to experimental animals.
No data on humans were available.
In the absence of epidemiological data, no evaluation of the
carcinogenicity of 2,6-dichloro-para-phenylenediamine to humans could
be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 3)
Synonyms
- C.I. 37020
- Daito Brown Salt RR
- 1,4-Diamino-2,6-dichlorobenzene
- 2,5-Diamino-1,3-dichlorobenzene
- 2,6-Dichloro-1,4-benzenediamine
- 2,6-Dichloro-1,4-phenylenediamine
- 3,5-Dichloro-1,4-phenylenediamine
- Fast Brown RR Salt
Last updated: 21 April 1998