International Agency for Research on Cancer (IARC) - Summaries & Evaluations
3,3'-DIMETHOXYBENZIDINE-4,4'-DIISOCYANATE
VOL.: 39 (1986) (p. 279)
CAS No.: 91-93-0
Chem. Abstr. Name: 1,1'-Biphenyl, 4,4'-diisocyanato-3,3'-
5. Summary of Data Reported and Evaluation
5.1 Exposure data
3,3'-Dimethoxybenzidine-4,4'-diisocyanate has been used in
isocyanate-based adhesives and as a components of polyurethane
elastomers. There is no evidence of current exposure.
5.2 Experimental data
3,3'-Dimethoxybenzidine-4,4'-diisocyanate was tested for
carcinogenicity in one study in mice by administration in the diet and
in one study in rats by gavage followed by dietary administration. No
treatment-related tumour was observed in mice. A statistically
significant increase in the combined incidence of leukaemia and
malignant lymphomas was observed in both male and female rats,
together with a treatment-related increase in the incidence of tumours
of the skin and Zymbal gland. Increases in the incidence of
endometrial stromal polyps were observed in female rats.
No data were available to evaluate the reproductive effects or
prenatal toxicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to
experimental animals.
3,3'-Dimethoxybenzidine-4,4'-diisocyanate was mutagenic to
Salmonella typhimurium in the presence of an exogenous metabolic
system.
5.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to
humans.
No case report or epidemiological study was available to evaluate
the carcinogenicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to
humans.
5.4 Evaluation
There is limited evidence for the carcinogenicity of
3,3'-dimethoxybenzidine-4,4'-diisocyanate to experimental animals.
No data on humans were available.
In the absence of epidemiological data, no evaluation of the
carcinogenicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to humans
could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 3)
Synonyms
- DADI
- Dianisidine diisocyanate
- 3,3'-Dimethoxy-4,4'-biphenyl diisocyanate
- 3,3'-Dimethoxy-4,4'-biphenylene diisocyanate
- 3,3'-Dimethoxy-4,4'-biphenylylene isocyanate
- 3,3'-Dimethoxy-4,4'-biphenylene isocyanic acid ester
- 3,3'-Dimethoxy-4,4'-diphenylyl isocyanate
- Isocyanic acid, 3,3'-dimethoxy-4,4'-biphenylene ester
- NCI-CO2175
Last updated: 21 April 1998