International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 40 (1986) (p. 67)

CAS No.: 518-75-2
Chem. Abstr. Name: (3R-trans)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6- oxo-3H-2-benzopyran-
7-carboxylic acid

5. Summary of Data Reported and Evaluation

5.1 Exposure

Citrinin is produced by various Penicillium and Aspergillus species that can contaminate foodstuffs, and has been found in some cereals and fruits and peanuts. Thus, human exposure can occur by ingestion of such contaminated products.

5.2 Experimental data

Citrinin was adequately tested for carcinogenicity in one experiment in one strain of male rats by oral administration in the diet; it produced renal tumours. In another experiment in rats, citrinin was administered in the diet after N-nitrosodimethylamine or N-(3,5-dichlorophenyl)succinimide; an increased incidence of renal tumours was observed as compared to that in animals receiving N-nitrosodimethylamine or N-(3,5-dichlorophenyl)succinimide alone.

In rodents, embryotoxicity occurred after injection of maternally toxic doses of citrinin.

Both positive and negative results have been reported with citrinin in the Bacillus subtilis rec assay; the compound was not mutagenic in Salmonella typhimurium in the presence or absence of an exogenous metabolic system. It did not induce recombination in Saccharomyces cerevisiae nor unscheduled DNA synthesis in mammalian cells in vitro. Chromosomal aberrations but no sister chromatid exchanges were induced by citrinin in Chinese hamster V79 cells in the presence of an exogenous metabolic system.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of citrinin was available to the Working Group.

5.4 Evaluation

There is limited evidence for the carcinogenicity of citrinin to experimental animals.

No evaluation could be made of the carcinogenicity of citrinin to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 60: Group 3)


Last updated: 22 April 1998

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