International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 40 (1986) (p. 222)

CAS No.: 67730-11-4
Chem. Abstr. Name: 6-Methyldipyrido[1,2-a:3',2'-d]imidazol-2-amine

5. Summary of Data Reported and Evaluation

5.1 Exposure

Glu-P-1 (2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole) is found at low levels among the pyrolysis products of L-glutamic acid and casein, and human exposure may occur by ingestion of cooked foods containing these substances.

5.2 Experimental data

Glu-P-1 was tested for carcinogenicity in one experiment in mice and one experiment in rats by oral administration in the diet. It produced haemangioendotheliomas and haemangioendothelial sarcomas at various sites and hepatocellular adenomas in mice of each sex and liver carcinomas in female mice. In rats, it produced benign and malignant tumours of the liver, intestines and Zymbal gland in animals of each sex and tumours of the clitoral gland in females.

No data were available to evaluate the reproductive effects or prenatal toxicity of this compound to experimental animals.

Glu-P-1 induced prophage in bacteria. It was mutagenic in Salmonella typhimurium in the presence of an exogenous metabolic system, and gave positive results in the wing spot test in Drosophila melanogaster. Glu-P-1 induced mutations, chromosomal aberrations, sister chromatid exchanges and morphological transformation in cultured mammalian cells. It induced DNA damage in rats treated in vivo and positive results in the mouse spot test.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of Glu-P-1 was available to the Working Group.

5.4 Evaluation

There is sufficient evidence for the carcinogenicity of Glu-P-1 to experimental animals.

No data were available on the carcinogenicity of Glu-P-1 to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 2B)


Last updated: 23 April 1998

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