International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 40 (1986) (p. 235)

CAS No.: 67730-10-3
Chem. Abstr. Name: Dipyrido[1,2-a:3',2'-d]imidazo1-2-amine

5. Summary of Data Reported and Evaluation

5.1 Exposure

Glu-P-2 (2-aminodipyrido[1,2-a:3',2'-d]imidazole) has been found in grilled fish and in L-glutamic acid and casein pyrolysates; therefore, consumption of grilled foods may result in human exposure.

5.2 Experimental data

Glu-P-2 was tested for carcinogenicity in one experiment in mice and one experiment in rats by oral administration in the diet. In mice, it produced haemangioendotheliomas and haemangioendothelial sarcomas at various sites and hepatocellular adenomas and carcinomas in animals of each sex. In rats, it produced benign and malignant tumours of the liver, intestines and zymbal gland in animals of each sex and tumours of the clitoral gland in females.

No data were available to evaluate the reproductive effects or prenatal toxicity of this compound to experimental animals.

Glu-P-2 induced prophage in bacteria. It was mutagenic in Salmonella typhimurium in the presence of an exogenous metabolic system and in cultured mammalian cells, and gave positive results in the wing spot test in Drosophila melanogaster. Experiments for the induction of sister chromatid exchanges and chromosomal aberrations in cultured mammalian cells were inadequate.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of Glu-P-2 was available to the Working Group.

5.4 Evaluation

There is sufficient evidence for the carcinogenicity of Glu-P-2 to experimental animals.

No data were available on the carcinogenicity of Glu-P-2 to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 2B)


Last updated: 22 April 1998

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