International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 40 (1986) (p. 253)

CAS No.: 68006-83-7
Chem. Abstr. Name: 3-Methyl-1H-pyrido[2,3-b]indol-2-amine

5. Summary of Data Reported and Evaluation

5.1 Exposure

MeA-a-C (2-amino-3-methyl)-9H-pyrido[2,3-b]indole has been found in grilled foods, in the pyrolysis products of proteins and in cigarette smoke. There is thus likely to be widespread human exposure to this compound.

5.2 Experimental data

MeA-a-C was tested for carcinogenicity in one experiment in mice by oral administration in the diet. It produced haemangioendothelial sarcomas at various sites and hepatocellular adenomas and carcinomas in animals of each sex.

No data were available to evaluate the reproductive effects or prenatal toxicity of this compound to experimental animals.

MeA-a-C induced prophage in bacteria. It induced DNA damage in Bacillus subtilis and was mutagenic in Salmonella typhimurium in the presence of an exogenous metabolic system. It gave positive results in the wing spot test in Drosophila melanogaster. In cultured Chinese hamster lung cells, MeA-a-C induced polyploidy in the absence, and chromosomal aberrations in the presence, of an exogenous metabolic system.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of MeA-a-C was available to the Working Group.

5.4 Evaluation

There is sufficient evidence for the carcinogenicity of MeA-a-C to experimental animals.

No data were available on the carcinogenicity of MeA-a-C to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 65: Group 2B)


Last updated: 22 April 1998

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