International Agency for Research on Cancer (IARC) - Summaries & Evaluations
1,2-DICHLOROPROPANE
VOL.: 41 (1986) (p. 131)
CAS No.: 78-87-5
5. Summary of Data Reported and Evaluation
5.1 Exposure data
1,2-Dichloropropane has been used as an industrial solvent, as a
chemical intermediate and in soil fumigants. Human exposure may occur
during its production and industrial and domestic use, and due to the
presence of low levels in ambient air and in water.
5.2 Experimental data
1,2-Dichloropropane was tested for carcinogenicity by oral
administration by gavage in one experiment in mice and one experiment
in rats. A dose-related increase in the incidence of hepatocellular
tumours was observed in male and female mice. Inconclusive results
were obtained with regard to female rats, and no effect was seen in
male rats.
No data were available to evaluate the reproductive effects or
prenatal toxicity of 1,2-dichloropropane to experimental animals.
1,2-Dichloropropane is mutagenic to Salmonella typhimurium but not to
Streptomyces coelicolor. It induces mutations but not chromosomal
effects in Aspergillus nidulans. It does not induce sex-linked
recessive lethal mutations in Drosophila melanogaster.
5.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of 1,2-dichloropropane to humans.
No case report or epidemiological study on the carcinogenicity of
1,2-dichloropropane to humans was available to the Working Group.
5.4 Evaluation
There is limited evidence for the carcinogenicity of
1,2-dichloropropane to experimental animals.
No evaluation could be made of the carcinogenicity of
1,2-dichloropropane to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol.71 (1999)
Synonyms
- ENT 15 406
- Propylene chloride
- Propylene dichloride
Last updated: 13 April 1999