International Agency for Research on Cancer (IARC) - Summaries & Evaluations
2-CHLORO-1,1,1-TRIFLUOROETHANE
VOL.: 41 (1986) (p. 253)
CAS No.: 75-88-7
5. Summary of Data Reported and Evaluation
5.1 Exposure data
2-Chloro-1,1,1-trifluoroethane is used as a chemical intermediate in
the production of the anaesthetic halothane. Human exposure occurs due
to its presence as a low-level impurity in, and at metabolite of,
halothane.
5.2 Experimental data
2-Chloro-1,1,1-trifluoroethane was tested for carcinogenicity in one
experiment in rats by oral administration by gavage at one dose level.
Increased incidences of uterine carcinomas and benign testicular
tumours were observed.
No data were available to evaluate the reproductive effects or
prenatal toxicity of 2-chloro-1,1,1-trifluoroethane to experimental
animals.
2-Chloro-1,1,1-trifluoroethane is not mutagenic to Salmonella
typhimurium in the presence or absence of an exogenous metabolic
system.
5.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of 2-chloro-1,1,1-trifluoroethane to humans.
No case report or epidemiological study of the carcinogenicity of
2-chloro-1,1,1-trifluoroethane to humans was available to the Working
Group.
5.4 Evaluation
There is limited evidence for the carcinogenicity of
2-chloro-1,1,1-trifluoroethane to experimental animals.
No evaluation could be made of the carcinogenicity of
2-chloro-1,1,1-trifluoroethane to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
Synonyms
- 1-Chloro-2,2,2-trifluoroethane
- CFC 133a
- FC 133a
- R 133a
- 2,2,2-Trifluorochloroethane
- 1,1,1-Trifluoro-2-chloroethane
- 1,1,1-Trifluoroethyl chloride
Last updated: 13 April 1999