VOL.: 41 (1986) (p. 319)
Three studies have been published in which cytogenetic effects were investigated in workers exposed occupationally to chlorophenols. In two of the studies, no difference was seen between exposed and control subjects; but in one of these studies the persons were examined ten years after exposure. The other study showed increased incidences of dicentric and acentric chromosomal aberrations, but not of gaps, chromatid breaks or sister chromatid exchanges.
Several cohort studies have been conducted among chemical industry workers with potential exposure to 2,4,5-trichlorophenol, TCDD and other chemicals. Mortality rates for all cancers combined were not elevated. In a Danish cohort study, there may have been exposure to chlorophenols, present as intermediates in the production of chlorophenoxy herbicides. No increase in the incidence of cancers at all sites combined was observed, but there were statistically significantly increased risks of soft-tissue sarcoma and lung cancer in different subcohorts.
Two case-control studies conducted in different regions of Sweden showed a statistically significant association between exposure to chlorophenols and soft-tissue sarcoma; a study from New Zealand did not.
A statistically significant association between malignant lymphoma and exposure to chlorophenols was identified in a Swedish case-control study. A case-control study of non-Hodgkin's lymphoma in New Zealand suggested a possible association with fencing work, but not with other occupational exposures to chlorophenols.
A case-control study in Sweden detected a significant association between nasal and nasopharyngeal cancer and exposure to chlorophenols, independent of exposure to wood dust.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations