VOL.: 42 (1987) (p. 185)
No teratogenic effect was observed in rats, mice, hamsters or rabbits following oral administration of talc.
Talc was not mutagenic to Salmonella typhimurium or Saccharomyces cerevisiae. It did not induce chromosomal aberrations in cultured human cells or in rats in vivo or dominant lethal mutations in rats.
Proportionate mortality studies of miners and millers of talc containing asbestiform tremolite and anthophyllite showed an excess of lung cancer and one case of mesothelioma. A cohort study of workers in one company revealed significant excess mortality from lung cancer and from nonmalignant respiratory disease. Mortality from lung cancer increased with latency.
In several mortality studies, cancer risk was assessed among miners and millers of talc that was reported to contain no more than trace amounts of asbestiform minerals. A cohort mortality study of talc miners and millers showed an excess of lung cancer in underground miners but not in millers; a contributory etiological role of radon daughters to the lung cancer risk in miners could not be excluded. Three other studies suffered from methodological limitations and could not be interpreted.
A case-control study suggested an approximate doubling of the risk for ovarian cancer among women after perineal use of talc.
There is inadequate evidence for the carcinogenicity to humans of talc not containing asbestiform fibres, while there is sufficient evidence for the carcinogenicity to humans of talc containing asbestiform fibres.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations TALC (JECFA Evaluation) Talc (IARC Summary & Evaluation, Supplement7, 1987)