International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 46 (1989) (p. 201)

CAS No.: 75321-20-9
Chem. Abstr. Name: Pyrene, 1,3-dinitro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

1,3-Dinitropyrene has been detected in some carbon blacks and in particulate emissions from diesel engines, kerosene heaters and gas burners. It has been found at low concentrations in ambient air.

5.2 Experimental data

1,3-Dinitropyrene was tested for carcinogenicity in single experiments in rats by oral administration, in mice, rats and newborn rats by subcutaneous injection and in newborn mice and in weanling rats by intraperitoneal injection. It was carcinogenic to rats, producing sarcomas at the site of its subcutaneous injection. The tests by oral and intraperitoneal routes in rats and by subcutaneous and intraperitoneal injection in mice were inadequate for evaluation.

5.3 Human data

No data were available to the Working Group.

5.4 Other relevant data

Metabolism of 1,3-dinitropyrene led to DNA binding in vitro. 1,3-Dinitropyrene caused DNA damage and mutation in cultured rodent and human cells and in bacteria. It did not cause gene conversion in yeast.

5.5 Evaluation

There is limited evidence for the carcinogenicity in experimental animals of 1,3-dinitropyrene.

No data were available from studies in humans on the carcinogenicity of 1,3-dinitropyrene.

Overall evaluation

1,3-Dinitropyrene is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Last updated 01/21/98

    See Also:
       Toxicological Abbreviations