International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 2B)

For definition of Groups, see Preamble Evaluation.

VOL.: 46 (1989) (p. 215)

CAS No.: 42397-64-8
Chem. Abstr. Name: Pyrene, 1,6-dinitro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

1,6-Dinitropyrene has been detected in some carbon blacks and in particulate emissions from diesel engines, kerosene heaters and gas burners. It has also been found at low concentrations in ambient air.

5.2 Experimental data

1,6-Dinitropyrene was tested for carcinogenicity by intratracheal instillation in hamsters, by intrapulmonary injection in rats, by subcutaneous injection in mice and rats and by intraperitoneal injection in newborn mice and weanling rats. After intratracheal instillation, it induced adenocarcinomas of the lung and leukaemia. After intrapulmonary injection, it induced a high incidence of squamous-cell carcinomas of the lung. After subcutaneous injection, it induced a high incidence of sarcomas at the injection site in weanling and newborn rats and in mice and leukaemia in newborn rats. After intraperitoneal injection, it increased the incidence of liver-cell tumours in male mice and induced sarcomas of the peritoneal cavity in rats. A study by oral administration in rats was inadequate for evaluation.

5.3 Human data

No data were available to the Working Group.

5.4 Other relevant data

Metabolism of 1,6-dinitropyrene led to DNA adduct formation in vivo and in vitro. 1,6-Dinitropyrene induced DNA damage and chromosomal aberrations but not mutations in cultured human cells. It induced DNA damage, mutation, sister chromatid exchange and chromosomal aberrations in cultured rodent cells, and DNA damage and mutation in bacteria.

5.5 Evaluation

There is sufficient evidence for the carcinogenicity in experimental animals of 1,6-dinitropyrene.

No data were available from studies in humans on the carcinogenicity of 1,6-dinitropyrene.

Overall evaluation

1,6-Dinitropyrene is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Last updated 01/21/98

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