International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 46 (1989) (p. 291)

CAS No.: 86-57-7
Chem. Abstr. Name: Naphthalene, 1-nitro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

1-Nitronaphthalene is used as an intermediate in chemical synthesis. It has been detected in some carbon blacks and in particulate exhaust of diesel engines and has been found at low concentrations in ambient air.

5.2 Experimental data

1-Nitronaphthalene was tested for carcinogenicity in mice and rats by oral administration. No carcinogenic effect was observed, but the dose used did not induce toxic effects.

5.3 Human data

No data were available to the Working Group.

5.4 Other relevant data

N-Hydroxy-1-naphthylamine (which has been shown to induce tumours in experimental animals) has been detected as a metabolite of 1-nitronaphthalene in vitro. A single intraperitoneal injection of 1-nitronaphthalene to rats caused hepatotoxicity and necrosis of Clara cells of the lung. 1-Nitronaphthalene induced DNA damage and mutation in bacteria but was not mutagenic to Drosophila melanogaster.

4.5 Evaluation

There is inadequate evidence for the carcinogenicity in experimental animals of 1-nitronaphthalene.

No data were available from studies in humans on the carcinogenicity of 1-nitronaphthalene.

Overall evaluation

1-Nitronaphthalene is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Last updated 01/21/98

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       Toxicological Abbreviations