International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 2B)

For definition of Groups, see Preamble Evaluation.

VOL.: 46 (1989) (p. 367)

CAS No.: 57835-92-4
Chem. Abstr. Name: Pyrene, 4-nitro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

4-Nitropyrene was detected at a low concentration in ambient air in one study.

5.2 Experimental data

4-Nitropyrene was tested for carcinogenicity in newborn rats by subcutaneous injection, producing an increase in the incidence of mammary tumours. It was also tested by intraperitoneal injection in newborn mice, producing an increase in the incidence of liver-cell tumours in males and of lung tumours in animals of each sex. A study by intraperitoneal injection was inadequately reported.

5.3 Human data

No data were available to the Working Group.

5.4 Other relevant data

4-Nitropyrene induced DNA damage and mutation in bacteria.

5.5 Evaluation

There is sufficient evidence for the carcinogenicity in experimental animals of 4-nitropyrene.

No data were available from studies in humans on the carcinogenicity of 4-nitropyrene.

4-Nitropyrene is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Last updated 01/21/98

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       Toxicological Abbreviations