For definition of Groups, see Preamble Evaluation.
VOL.: 47 (1989) (p. 157)
Chem. Abstr. Name: Cyclohexanone
Cyclohexanone is a synthetic organic liquid used primarily as an intermediate in the production of nylon. Other minor applications are as an intermediate, additive and solvent in a variety of products. Occupational exposure levels have been measured in some industries.
Cyclohexanone was tested for carcinogenicity by oral administration in the drinking-water in one strain of mice and one strain of rats. In mice, there was a slight increase in the incidence of tumours that occur commonly in this strain, only in animals given the low dose. In rats, a slight increase in the incidence of adrenal cortical adenomas occurred in males treated with the low dose.
No data were available to the Working Group.
No significant systemic toxicity was reported in humans or experimental animals. No significant prenatal toxicity was observed in mice.
Cyclohexanone induced chromosomal aberrations and ploidy changes in cultured human cells and in rats. It did not induce mutation in bacteria.
There is inadequate evidence for the carcinogenicity of cyclohexanone in experimental animals.
No data were available from studies in humans on the carcinogenicity of cyclohexanone.
Cyclohexanone is not classifiable as to its carcinogenicity to humans (Group 3).
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
Last updated: 13 April 1999
See Also: Toxicological Abbreviations Cyclohexanone (ICSC) CYCLOHEXANONE (JECFA Evaluation) Cyclohexanone (IARC Summary & Evaluation, Volume 71, 1999)