International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 47 (1989) (p. 157)

CAS No.: 108-94-1
Chem. Abstr. Name: Cyclohexanone

5. Summary of Data Reported and Evaluation

5.1 Exposures

Cyclohexanone is a synthetic organic liquid used primarily as an intermediate in the production of nylon. Other minor applications are as an intermediate, additive and solvent in a variety of products. Occupational exposure levels have been measured in some industries.

5.2 Experimental carcinogenicity data

Cyclohexanone was tested for carcinogenicity by oral administration in the drinking-water in one strain of mice and one strain of rats. In mice, there was a slight increase in the incidence of tumours that occur commonly in this strain, only in animals given the low dose. In rats, a slight increase in the incidence of adrenal cortical adenomas occurred in males treated with the low dose.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

No significant systemic toxicity was reported in humans or experimental animals. No significant prenatal toxicity was observed in mice.

Cyclohexanone induced chromosomal aberrations and ploidy changes in cultured human cells and in rats. It did not induce mutation in bacteria.

5.5 Evaluation

There is inadequate evidence for the carcinogenicity of cyclohexanone in experimental animals.

No data were available from studies in humans on the carcinogenicity of cyclohexanone.

Overall evaluation

Cyclohexanone is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)


Last updated: 13 April 1999

    See Also:
       Toxicological Abbreviations
       Cyclohexanone (ICSC)
       CYCLOHEXANONE (JECFA Evaluation)
       Cyclohexanone  (IARC Summary & Evaluation, Volume 71, 1999)