International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (p. 109)

CAS No.: 115-96-8
Chem. Abstr. Name: Tris(2-chloroethyl)phosphate

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Tris(2-chloroethyl) phosphate is used as a flame retardant in plastics, especially in flexible foams used in automobiles and furniture, and in rigid foams used for building insulation. No data on occupational exposure levels were available. Tris(2-chloroethyl) phosphate has been detected in drinking-water, river water, sea water and sediments in various parts of the world.

5.2 Experimental carcinogenicity data

Tris(2-chloroethyl) phosphate was tested for initiating and promoting activity and for complete carcinogenicity in one strain of mice by skin application. No initiating activity was found; promoting activity and complete carcinogenicity could not be evaluated.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

In single studies, tris(2-chloroethyl) phosphate gave equivocal results in a micronucleus test in Chinese hamsters in vivo and caused dominant lethal mutation in rats. It caused cell transformation and, in single studies, sister chromatid exchange but not mutation in rodent cells in vitro. It was not mutagenic to bacteria in the absence of an exogenous metabolic system but gave equivocal results in the presence of an exogenous metabolic system.

5.5 Evaluation

There is inadequate evidence for the carcinogenicity of tris(2-chloroethyl) phosphate in experimental animals.

No data were available from studies in humans on the carcinogenicity of tris(2-chloro-ethyl) phosphate.

Overall evaluation

Tris(2-chloroethyl) phosphate is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)


Last updated: 13 April 1999

    See Also:
       Toxicological Abbreviations
       Tris(2-chloroethyl) phosphate (ICSC)
       Tris(2-chloroethyl) Phosphate  (IARC Summary & Evaluation, Volume 71, 1999)