International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (p. 139)

CAS No.: 2475-45-8
Chem. Abstr. Name: 9,10-Anthracenedione, 1,4,5,8-tetraamino-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Disperse Blue 1 is an aminoanthraquinone-based dyestuff used in hair colour formulations and in colouring fabrics and plastics. No data on occupational exposure levels were available.

5.2 Experimental carcinogenicity data

Disperse Blue 1 was tested for carcinogenicity by oral administration in one strain of mice and in one strain of rats. In mice, it produced an increase in the incidence of alveolar/bronchiolar adenomas and carcinomas (combined) and a marginal increase in the incidence of hepatocellular tumours in treated males. In rats of each sex, it produced transitional-cell papillomas and carcinomas, squamous-cell papillomas and carcinomas, and leiomyomas and leiomyosarcomas of the urinary bladder; in addition, urinary bladder calculi were observed in the groups of rats in which the incidence of urinary bladder neoplasms was increased. In male rats, the incidence of islet-cell adenomas and carcinomas of the pancreas was marginally increased.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

Calculi were observed in the urinary tract of rats and mice given Disperse Blue 1 in the diet. Urinary bladder lesions included epithelial hyperplasia in rats and mice and squamous metaplasia in rats. Hyperplasia of the transitional epithelium of the renal pelvis occurred in rats.

Disperse Blue 1 was mutagenic to bacteria in the presence and absence of an exogenous metabolic system.

5.5 Evaluation

There is sufficient evidence for the carcinogenicity of Disperse Blue 1 in experimental animals.

No data were available from studies in humans on the carcinogenicity of Disperse Blue 1.

Overall evaluation

Disperse Blue 1 is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms

• Acetate Blue G
• Acetoquinone Blue L
• Acetoquinone Blue R
• Acetylon Fast Blue G
• Amacel Blue GG
• Amacel Pure Blue B
• Artisil Blue SAP
• Artisil Blue SAP Conc
• Brasilazet Blue GR
• Celanthrene Pure Blue BRS
• Celliton Blue BB
• Celliton Blue BB-CF
• Celliton Blue Extra
• Celliton Blue G
• Celliton Blue GA
• Celliton Blue GA-CF
• CI Disperse Blue 1
• CI Solvent Blue 18
• Cibacet Blue 2GS
• Cibacet Sapphire Blue G
• Cilla Blue Extra
• Diacelliton Fast Blue R
• Dianix Blue QTA
• Disperse Fast Blue BR
• Duranol Brilliant Blue CB
• Durosperse Blue CTP
• Fenacet Blue G
• Fenacet Blue GE
• Grasol Blue 2GS
• Hisperse Blue PRB
• Intrasperse Printing Blue 2B
• Intrasperse Sapphire Blue G
• Kayalon Fast Blue BR
• Microsetile Blue EB
• Miketon Fast Blue
• Miketon Fast Blue B
• Nacelan Blue G
• Navicet Blue Extra
• Neosetile Blue EB
• Nyloquinone Blue 2J
• Oracet Sapphire Blue G
• Palacet Blue Extra
• Pamacel Pure Blue B-I
• Perliton Blue B
• Serinyl Blue 2G
• Serinyl Blue 3G
• Serinyl Blue 3GN
• Setacyl Blue 2GS
• Setacyl Blue 2GS II
• Solvent Blue 18
• Supracet Brilliant Blue 2GN
• Supracet Deep Blue R
• 1,4,5,8-Tetraaminoanthraquinone

Last updated 01/20/98

    See Also:
       Toxicological Abbreviations