International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (161)

CAS No.: 128-66-5
Chem. Abstr. Name: Dibenzo[b,def]chrysene-7,14-dione

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Vat Yellow 4 is an anthraquinone-type dyestuff which is used to colour fabrics and paper and in smoke-screen formulations for military use. No data on occupational exposure levels were available.

5.2 Experimental carcinogenicity data

Vat Yellow 4 was tested for carcinogenicity by oral administration in one strain of mice and in one strain of rats, producing an increased incidence of lymphomas and hepatocellular tumours in male mice.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

In a single study, Vat Yellow 4 was not mutagenic to bacteria in the presence or absence of an exogenous metabolic system.

5.5 Evaluation

There is limited evidence for the carcinogenicity of Vat Yellow 4 in experimental animals.

No data were available from studies in humans on the carcinogenicity of Vat Yellow 4.

Overall evaluation

Vat Yellow 4 is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.


Last updated 01/20/98

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