International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (p. 169)

CAS No.: 99-55-8
Chem. Abstr. Name: Benzenamine, 2-methyl-5-nitro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

5-Nitro-ortho-toluidine is used as an intermediate in the production of a wide assortment of pigments and azo dyes. No data on occupational exposure levels were available.

5.2 Experimental carcinogenicity data

5-Nitro-ortho-toluidine was tested for carcinogenicity by oral administration in one strain of mice and in one strain of rats. It produced an increase in the incidence of hepatocellular tumours in mice of each sex and a marginal increase in the incidence of hepatocellular carcinomas in male rats.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

5-Nitro-ortho-toluidine was mutagenic to bacteria in the presence and absence of an exogenous metabolic system.

5.5 Evaluation

There is limited evidence for the carcinogenicity of 5-nitro-ortho-toluidine in experimental animals.

No data were available from studies in humans on the carcinogenicity of 5-nitro-ortho-toluidine.

Overall evaluation

5-Nitro-ortho-toluidine is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.


Last updated 01/20/98

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