International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (p. 169)

CAS No.: 99-55-8
Chem. Abstr. Name: Benzenamine, 2-methyl-5-nitro-

5.1 Exposure data

5-Nitro-ortho-toluidine is used as an intermediate in the production of a wide assortment of pigments and azo dyes. No data on occupational exposure levels were available.

5.2 Experimental carcinogenicity data

5-Nitro-ortho-toluidine was tested for carcinogenicity by oral administration in one strain of mice and in one strain of rats. It produced an increase in the incidence of hepatocellular tumours in mice of each sex and a marginal increase in the incidence of hepatocellular carcinomas in male rats.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

5-Nitro-ortho-toluidine was mutagenic to bacteria in the presence and absence of an exogenous metabolic system.

5.5 Evaluation

There is limited evidence for the carcinogenicity of 5-nitro-ortho-toluidine in experimental animals.

No data were available from studies in humans on the carcinogenicity of 5-nitro-ortho-toluidine.

Overall evaluation

5-Nitro-ortho-toluidine is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms

• Amarthol Fast Scarlet G Base
• Amarthol Fast Scarlet G Salt
• 1-Amino-2-methyl-5-nitrobenzene
• 2-Amino-4-nitrotoluene
• Azoene Fast Scarlet GC Base
• Azoene Fast Scarlet GC Salt
• Azofix Scarlet G Salt
• Azogene Fast Scarlet G
• Azoic diazo component 12
• Dainichi Fast Scarlet G Base
• Daito Scarlet Base G
• Devol Scarlet B
• Devol Scarlet G Salt
• Diabase Scarlet G
• Diazo Fast Scarlet G
• Fast Red SG Base
• Fast Scarlet G
• Fast Scarlet G Base
• Fast Scarlet G Salt
• Fast Scarlet GC Base
• Fast Scarlet J Base
• Fast Scarlet J Salt
• Fast Scarlet M 4NT Base
• Fast Scarlet T Base
• Hiltonil Fast Scarlet G Base
• Hiltonil Fast Scarlet G Salt
• Hiltonil Fast Scarlet GC Base
• Kayaku Scarlet G Base
• Lake Scarlet G Base
• Lithosol Orange R Base
• 2-Methyl-5-nitroaniline
• 6-Methyl-3-nitroaniline
• Mitsui Scarlet G Base
• Naphthanil Scarlet G Base
• Naphtoelan Fast Scarlet G Base
• Naphtoelan Fast Scarlet G Salt
• 3-Nitro-6-methylaniline
• 4-Nitro-2-aminotoluene
• 5-Nitro-2-methylaniline
• 5-Nitro-2-toluidine
• PNOT
• Scarlet Base Ciba II
• Scarlet Base Irga II
• Scarlet base NSP
• Scarlet G Base
• Sugai Fast Scarlet G Base
• Symulon Scarlet G Base

Last updated 01/20/98

    See Also:
       Toxicological Abbreviations