International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 153)
CAS No.: 2871-01-4
Chem. Abstr. Name: 2-[(4-Amino-2-nitrophenyl)amino]ethanol

5.1 Exposure data

HC Red No. 3 is used as a semipermanent hair dye.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

HC Red No. 3 was tested for carcinogenicity by gavage in one study in mice and in one study in rats. There was a significant increase in the incidence of hepatocellular adenomas and carcinomas combined in male mice administered the high dose; poor survival precluded evaluation of the females. No increase in the incidence of treatment-related tumours was seen in rats of either sex.

5.4 Other relevant data

HC Red No. 3 was mutagenic to bacteria.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of HC Red No. 3.

There is inadequate evidence in experimental animals for the carcinogenicity of HC Red No. 3.

Overall evaluation

HC Red No. 3 is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms

• 2-(4-Amino-2-nitroanilino)ethanol
• HC Red 3
• HC Red Number 3
• 4-(2-Hydroxyethyl)amino-3-nitroaniline
• N¹-(2-Hydroxyethyl)-2-nitro-para-phenylenediamine

    See Also:
       Toxicological Abbreviations