For definition of Groups, see Preamble Evaluation.
VOL.: 57 (1993) (p. 159)
Chem. Abstr. Name: 2-[(2-[2-Hydroxyethoxy]-4-nitrophenyl)amino]ethanol
HC Yellow No. 4 is used as a semipermanent hair dye.
No data were available to the Working Group.
HC Yellow No. 4 was tested for carcinogenicity by administration in the diet in one study in mice and in one study in rats. No significant increase in tumour incidence was found in mice. The incidence of adenomas of the pituitary gland was increased in male rats but not in females.
HC Yellow No. 4 induced gene mutation in bacteria and in insects. Chromosomal aberrations were not induced in insects, and equivocal results for this end-point were obtained in cultured mammalian cells. Sister chromatid exchange was induced in mammalian cells.
There is inadequate evidence in humans for the carcinogenicity of HC Yellow No. 4.
There is inadequate evidence in experimental animals for the carcinogenicity of HC Yellow No. 4.
HC Yellow No. 4 is not classifiable as to its carcinogenicity to humans (Group 3).
For definition of the italicized terms, see Preamble Evaluation.
See Also: Toxicological Abbreviations