International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 167)
CAS No.: 99-57-0
Chem. Abstr. Name: 2-Amino-4-nitrophenol

5.1 Exposure data

2-Amino-4-nitrophenol is used as an intermediate in the manufacture of certain azo dyes. It is also used in semipermanent hair colouring products and has been used in permanent hair colours.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

2-Amino-4-nitrophenol was tested for carcinogenicity by gavage in one study in mice and one study in rats. No significant increase in the incidence of tumours was observed in mice or in female rats. The incidence of renal-cell adenomas was increased in male rats.

5.4 Other relevant data

2-Amino-4-nitrophenol caused renal toxicity in rats and mice. The effect occurred at a lower dose in male than in female rats.

2-Amino-4-nitrophenol induced mutation in bacteria, fungi and cultured mammalian cells and sister chromatid exchange and chromosomal aberrations in cultured mammalian cells. It did not induce micronuclei, chromosomal aberrations or dominant lethal mutation in rodents exposed in vivo.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of 2-amino-4-nitrophenol.

There is limited evidence in experimental animals for the carcinogenicity of 2-amino-4-nitrophenol.

Overall evaluation

2-Amino-4-nitrophenol is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms

• 1-Amino-2-hydroxy-5-nitrobenzene
• CI No. 76530
• 1-Hydroxy-2-amino-4-nitrobenzene
• 2-Hydroxy-5-nitroaniline
• 4-Nitro-2-aminophenol
• para-Nitro-ortho-aminophenol
• Rodol 42

    See Also:
       Toxicological Abbreviations