International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 247)
CAS No.: 6459-94-5
Chem. Abstr. Name: 8-[(3,3'-Dimethyl-4'-[(4-[([4-methylphenyl]sulfonyl)oxy]phenyl)azo][1,1'-biphenyl]-4-yl)azo]-7-hydroxy-
1,3-naphthalenedisulfonic acid, disodium salt

5.1 Exposure data

CI Acid Red 114, a bis-azo dye derived from 3,3'-dimethylbenzidine, is used to dye wool, silk, jute and leather.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

CI Acid Red 114 was tested for carcinogenicity in one study in rats by administration in the drinking-water. It increased the incidences of benign and malignant tumours of the skin, Zymbal gland and liver in male and female rats, and of the clitoral gland, lung, oral cavity and small and large intestine in female rats.

5.4 Other relevant data

Reductive cleavage of the azo bonds to yield 3,3'-dimethylbenzidine was demonstrated in vivo.

CI Acid Red 114 induced gene mutation in bacteria under reducing conditions. It did not induce gene mutation in insects or sister chromatid exchange or chromosomal aberrations in cultured mammalian cells.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of CI Acid Red 114.

There is sufficient evidence in experimental animals for the carcinogenicity of CI Acid Red 114.

Overall evaluation

CI Acid Red 114 is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms

• Acid Leather Red BG
• Acid Red 114
• Amacid Milling Red PRS
• Benzyl Fast Red BG
• Benzyl Red BR
• CI Acid Red 114, disodium salt
• CI No. 23635
• Elcacid Milling Fast Red RS
• Erionyl Red RS
• Fenafor Red PB
• Folan Red B
• Intrazone Red BR
• Kayanol Milling Red RS
• Leather Fast Red B
• Levanol Red GG
• Midlon Red PRS
• Milling Fast Red B
• Milling Red B
• Milling Red BB
• Milling Red SWB
• Polar Red RS
• Sandolan Red N-RS
• Sella Fast Red RS
• Sulphonol Red R
• Suminol Milling Red RS
• Supranol Fast Red 3G
• Supranol Fast Red GG
• Supranol Red PBX-CF
• Supranol Red R
• Telon Fast Red GG
• Tertracid Milling Red B
• Vondamol Fast Red RS

    See Also:
       Toxicological Abbreviations