International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 259)
CAS No.: 2425-85-6
Chem. Abstr. Name: 1-[(4-Methyl-2-nitrophenyl)azo]-2-naphthalenol

5.1 Exposure data

CI Pigment Red 3, one of the most widely used red pigments, is found in paints, inks, plastics, rubber and textiles.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

CI Pigment Red 3 was tested for carcinogenicity by administration in the diet in one study in mice and in one study in rats. In male mice, it induced follicular-cell adenomas of the thyroid and renal-cell adenomas. There was an increased incidence of adrenal phaeochromocytomas in male rats and of hepatocellular adenomas in female rats.

5.4 Other relevant data

CI Pigment Red 3 did not induce gene mutation in bacteria or sister chromatid exchange or chromosomal aberrations in cultured mammalian cells.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of CI Pigment Red 3.

There is limited evidence in experimental animals for the carcinogenicity of CI Pigment Red 3.

Overall evaluation

CI Pigment Red 3 cannot be classified as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms

• Accosperse Toluidine Red XL
• ADC Toluidine Red B
• Atlasol Spirit Red 3
• CI No. 12120
• CP Toluidine Toner A 2989
• CP Toluidine Toner A 2990
• CP Toluidine Toner Dark RS 3340
• CP Toluidine Toner Deep X 1865
• CP Toluidine Toner Light RS 3140
• CP Toluidine Toner RT 6101
• CP Toluidine Toner RT 6104
• Calcotone Toluidine Red YP
• Carnelio Helio Red
• Chromatex Red J
• Dainichi Permanent Red 4R
• D&C Red No. 35
• D and C Red No. 35
• Deep Fastona Red
• Duplex Toluidine Red L 20-3140
• Eljon Fast Scarlet PV Extra
• Eljon Fast Scarlet RN
• Enialit Light Red RL
• Fast Red A
• Fast Red AB
• Fast Red J
• Fast Red JE
• Fast Red R
• Fastona Red B
• Fastona Scarlet RL
• Fastona Scarlet YS
• Graphtol Red A 4RL
• Hansa Red B
• Hansa Red G
• Hansa Scarlet RB
• Hansa Scarlet RN
• Hansa Scarlet RNC
• Helio Fast Red BN
• Helio Fast Red RL
• Helio Fast Red RN
• Helio Red RL
• Helio Red Toner
• Hispalit Fast Scarlet RN
• Independence Red
• Irgalite Fast Red P 4R
• Irgalite Fast Scarlet RND
• Irgalite Red PV 2
• Irgalite Red RNPX
• Irgalite Scarlet RB
• Isol Fast Red HB
• Isol Fast Red RN 2B
• Isol Fast Red RN 2G
• Isol Fast Red RNB
• Isol Fast Red RNG
• Isol Toluidine Red HB
• Isol Toluidine Red RN 2B
• Isol Toluidine Red RN 2G
• Isol Toluidine Red RNB
• Isol Toluidine Red RNG
• Japan Red 221
• Japan Red No. 221
• Kromon Helio Fast Red
• Kromon Helio Fast Red YS
• Lake Red 4R
• Lake Red 4RII
• Lithol Fast Scarlet RN
• Lutetia Fast Red 3R
• Lutetia Fast Scarlet RF
• Lutetia Fast Scarlet RJN
• 1-(4-Methyl-2-nitrophenylazo)-2-naphthol
• Monolite Fast Scarlet CA
• Monolite Fast Scarlet GSA
• Monolite Fast Scarlet RB
• Monolite Fast Scarlet RBA
• Monolite Fast Scarlet RN
• Monolite Fast Scarlet RNA
• Monolite Fast Scarlet RNV
• Monolite Fast Scarlet RT
• 1-[(2-Nitro-4-methylphenyl)azo]-2-naphthol
• 1-(ortho-nitro-para-tolylazo)-2-naphthol
• No. 2 Forthfast Scarlet
• Oralith Red P 4R
• Permanent Red 4R
• Pigment Red 3
• Pigment Red RL
• Pigment Scarlet
• Pigment Scarlet B
• Pigment Scarlet N
• Pigment Scarlet R
• Polymo Red FGN
• Recolite Fast Red RBL
• Recolite Fast Red RL
• Recolite Fast Red RYL
• Sanyo Scarlet Pure
• Sanyo Scarlet Pure No. 1000
• Scarlet Pigment RN
• Segnale Light Red 2B
• Segnale Light Red B
• Segnale Light Red BR
• Segnale Light Red C 4R
• Segnale Light Red RL
• Seikafast Red 4R4016
• Siegle Red 1
• Siegle Red B
• Siegle Red BB
• Silogomma Red RLL
• Silosol Red RBN
• Silosol Red RN
• Siloton Red BRLL
• Siloton Red RLL
• Symuler Fast Red 4R100
• Symuler Fast Scarlet 4R
• Syton Fast
• Scarlet RB
• Syton Fast Scarlet RD
• Syton Fast Scarlet RN
• Tertropigment Red HAB
• Tertropigment Scarlet LRN
• Toluidine red
• Toluidine Red 10451
• Toluidine Red 3B
• Toluidine Red 4R
• Toluidine Red BFB
• Toluidine Red BFGG
• Toluidine Red D28-3930
• Toluidine Red Light
• Toluidine Red M 20-3785
• Toluidine Red R
• Toluidine Red RT 115
• Toluidine Red Toner
• Toluidine Red XL 20-3050
• Toluidine Toner
• Toluidine Toner Dark 5040
• Toluidine Toner HR-X 2700
• Toluidine Toner HR-X 2741
• Toluidine Toner Keep HR-X 2742
• Toluidine Toner L 20-3300
• Toluidine Toner RT 252
• Versal Scarlet PRNL
• Versal Scarlet RNL
• Vulcafor Scarlet A

    See Also:
       Toxicological Abbreviations