International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 71 (1999) (p. 359)

CAS No.: 141-32-2
Chem. Abstr. Name: 2-Propenoic acid, butyl ester

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Exposure to n-butyl acrylate may occur in its manufacture and its use in the production of polymers and other chemical products. It has been detected at low levels in ambient air and water.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

n-Butyl acrylate was tested in one study in mice by skin application and in one study in rats by inhalation exposure. No carcinogenic effect was observed.

5.4 Other relevant data

n-Butyl acrylate is rapidly absorbed and hydrolysed in experimental animals exposed orally. Exposure of rats to n-butyl acrylate vapours leads to hyperplasia of the nasal mucosa. In assays for genotoxicity/mutagenicity considered, results for n-butyl acrylate were generally negative.

5.5 Evaluation

No epidemiological data relevant to the carcinogenicity of n-butyl acrylate were available.

There is inadequate evidence in experimental animals for the carcinogenicity of n-butyl acrylate.

Overall evaluation

n-Butyl acrylate is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluations: Vol. 39 (1986); Suppl. 7


Last updated: 12 April 1999

    See Also:
       Toxicological Abbreviations