For definition of Groups, see Preamble Evaluation.
VOL.: 71 (1999) (p. 531)
CAS No.:
Chem. Abstr. Name: Dimethylcarbamic chloride
5.1 Exposure data
Exposure to dimethylcarbamoyl chloride may occur during its manufacture and its use as an intermediate in the manufacture of a number of pharmaceuticals and pesticides.
5.2 Human carcinogenicity data
No deaths from cancer were reported in a small study of workers exposed for periods ranging from six months to 12 years.
5.3 Animal carcinogenicity data
Dimethylcarbamoyl chloride was tested for carcinogenicity in rats and hamsters by inhalation exposure, producing malignant tumours of the nasal cavity. It was also tested in mice by skin application and by subcutaneous and intraperitoneal injection, producing local tumours.
5.4 Other relevant data
No data were available on the metabolism of dimethylcarbamoyl chloride, but it rapidly decomposes on contact with water to dimethylamine, hydrochloric acid and carbon dioxide.
Dimethylcarbamoyl chloride when inhaled by rats damages the nasal mucous membrane, throat and lung.
It has a wide spectrum of genotoxic activity, which is expressed as a result of its direct alkylating activity.
5.5 Evaluation
There is inadequate evidence in humans for the carcinogenicity of dimethylcarbamoyl chloride.
There is sufficient evidence in experimental animals for the carcinogenicity of dimethylcarbamoyl chloride.
Overall evaluation
Dimethylcarbamoyl chloride is probably carcinogenic to humans (Group 2A).
In making the overall evaluation, the Working Group took into consideration that dimethylcarbamoyl chloride is a direct-acting alkylating agent with a wide spectrum of genotoxic activity, including activity in somatic cells in vivo.
For definition of the italicized terms, see Preamble Evaluation.Previous evaluations: Vol. 12 (1976); Suppl. 7 (1987)
See Also:
Toxicological Abbreviations