For definition of Groups, see Preamble Evaluation.
VOL.: 71 (1999) (p. 923)
CAS No.:
Chem. Abstr. Name: Bromoethene
5.1 Exposure data
Occupational exposure may occur during the production of vinyl bromide and its polymers.
5.2 Human carcinogenicity data
No data were available to the Working Group.
5.3 Animal carcinogenicity data
Vinyl bromide was tested in female mice by skin application and by subcutaneous injection, and in rats by inhalation exposure. In the inhalation study in rats, there was a dose-related increase in the incidence of liver angiosarcomas and Zymbal gland carcinomas; an increased incidence of liver neoplastic nodules and hepatocellular carcinoma was also noted.
5.4 Other relevant data
Vinyl bromide was mutagenic to Salmonella typhimurium and Drosophila melanogaster.
5.5 Evaluation
No epidemiological data relevant to the carcinogenicity of vinyl bromide were available.
There is sufficient evidence in experimental animals for the carcinogenicity of vinyl bromide.
Overall evaluation
Vinyl bromide is probably carcinogenic to humans (Group 2A).
In making the overall evaluation, the Working Group took into consideration that all available studies showed a consistently parallel response between vinyl bromide and vinyl chloride. In addition, both vinyl chloride and vinyl bromide are activated via a P450-dependent pathway to their corresponding epoxides. For both vinyl chloride and vinyl bromide, the covalent binding of these compounds to DNA forms the respective etheno adducts. The weight of positive evidence for both compounds was also noted among the studies for genotoxicity, although the number and variety of tests for vinyl bromide were fewer.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluations: Vol. 19 (1979); Vol. 39 (1986); Suppl. 7
Synonym
See Also:
Toxicological Abbreviations
Vinyl bromide (ICSC)