VOL.: 77 (2000) (p. 341)
Chem. Abstr. Name: 5-Chloro-2-methylbenzenamine
5. Summary of Data Reported and Evaluation
5.1 Exposure data
5-Chloro-ortho-toluidine is an aromatic amine which is produced in relatively small quantities as an intermediate in the manufacture of some pigments and azo dyes. No data were available on human exposure.
5.2 Human carcinogenicity data
No data were available to the Working Group.
5.3 Animal carcinogenicity data
5-Chloro-ortho-toluidine was tested for carcinogenicity by oral administration in one experiment in mice and in one experiment in rats. In mice, it increased the incidence of haemangiosarcomas (mostly of adipose tissue) and of hepatocellular carcinomas in both males and females. In rats, no carcinogenic effect was observed.
5.4 Other relevant data
5-Chloro-ortho-toluidine undergoes an initial metabolic activation step, probably via N-oxidation, to form a nitrosoarene that can bind covalently to haemoglobin.
The few available genotoxicity test results on 5-chloro-ortho-toluidine were negative.
No epidemiological data relevant to the carcinogenicity of 5-chloro-ortho-toluidine were available.
There is limited evidence in experimental animals for the carcinogenicity of 5-chloro-ortho-toluidine.
5-Chloro-ortho-toluidine is not classifiable as to its carcinogenicity to humans (Group 3).For definition of the italicized terms, see Preamble Evaluation.
See Also: Toxicological Abbreviations