International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 79 (2001) (p. 649)

CAS No.: 105-55-5
Chem. Abstr. Name: N,N-Diethylthiourea

5.  Summary of Data Reported and Evaluation

5.1 Exposure data

N,N-Diethylthiourea is used in the manufacture of some types of rubber and paint.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

N,N-Diethylthiourea was tested for carcinogenicity by dietary administration in one experiment each in mice and rats. Thyroid follicular-cell adenomas and carcinomas were induced in rats of each sex, but no increase in the incidence of tumours at any site was seen in mice.

5.4 Other relevant data

No data were available on the absorption, distribution, metabolism or excretion of N,N-diethylthiourea. The only toxic effect seen in humans was contact dermatitis. No data were available on the reproductive or developmental effects of this compound.

N,N-Diethylthiourea did not cause mutation in bacteria or insects. In single studies, it showed mutagenic activity in mouse lymphoma cells, in the absence of metabolic activation, and it transformed hamster embryo cells in culture.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of N,N-diethylthiourea.

There is limited evidence in experimental animals for the carcinogenicity of N,N-diethylthiourea.

Overall evaluation

N,N-Diethylthiourea is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.


Last updated: 25 September 2001

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