ICSC 0453 - 3,4-XYLIDINE

3,4-XYLIDINE	ICSC: 0453 (April 2007)
3,4-Dimethylaniline 3,4-Dimethylbenzeneamine 1-Amino-3,4-dimethylbenzene 4-Amino-o-xylene 4-Amino-1,2-xylene

CAS #: 95-64-7

UN #: 3452

EC Number: 202-437-4

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 98°C explosive vapour/air mixtures may be formed.	NO open flames. Above 98°C use a closed system and ventilation.	Use water spray, carbon dioxide, foam, powder.

STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Dizziness. Drowsiness. Headache. Nausea.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! See Ingestion.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes		Wear safety spectacles or eye protection in combination with breathing protection.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Ingestion	Blue lips, fingernails and skin. Dizziness. Drowsiness. Headache. Nausea. Unconsciousness.	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit and filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers.	According to UN GHS Criteria WARNING Harmful if swallowed May cause drowsiness and dizziness May cause damage to blood May cause damage to blood through prolonged or repeated exposure Toxic to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from strong oxidants, acids, acid anhydrides, acid chlorides, hypochlorites, halogens and food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs.

3,4-XYLIDINE

ICSC: 0453

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance WHITE SOLID IN VARIOUS FORMS WITH CHARACTERISTIC ODOUR. TURNS REDDISH TO BROWN ON EXPOSURE TO AIR. Physical dangers Chemical dangers Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides. Reacts violently with strong oxidants. Reacts with hypochlorites. This produces explosive chloroamines. Reacts with acids, acid anhydrides, acid chlorides and halogens. Attacks plastic and rubber.	Formula: C₈H₁₁N / (CH₃)₂C₆H₃NH₂ Molecular mass: 121.2 Boiling point: 228°C Melting point: 51°C Relative density (water = 1): 1.07 Solubility in water, g/100ml at 22°C: 0.38 Vapour pressure, Pa at 25°C: 4 Relative vapour density (air = 1): 4.19 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 98°C Auto-ignition temperature: 580°C Octanol/water partition coefficient as log Pow: 1.84

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE SOLID IN VARIOUS FORMS WITH CHARACTERISTIC ODOUR. TURNS REDDISH TO BROWN ON EXPOSURE TO AIR.

Physical dangers

Chemical dangers
Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides. Reacts violently with strong oxidants. Reacts with hypochlorites. This produces explosive chloroamines. Reacts with acids, acid anhydrides, acid chlorides and halogens. Attacks plastic and rubber.

Formula: C₈H₁₁N / (CH₃)₂C₆H₃NH₂
Molecular mass: 121.2
Boiling point: 228°C
Melting point: 51°C
Relative density (water = 1): 1.07
Solubility in water, g/100ml at 22°C: 0.38
Vapour pressure, Pa at 25°C: 4
Relative vapour density (air = 1): 4.19
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 98°C
Auto-ignition temperature: 580°C
Octanol/water partition coefficient as log Pow: 1.84

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body in hazardous amounts by inhalation, through the skin and by ingestion. Effects of short-term exposure Exposure at high levels could cause lowering of consciousness and formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.	Inhalation risk A harmful contamination of the air will be reached slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in anaemia.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body in hazardous amounts by inhalation, through the skin and by ingestion.

Effects of short-term exposure
Exposure at high levels could cause lowering of consciousness and formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air will be reached slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in anaemia.

OCCUPATIONAL EXPOSURE LIMITS
MAK: skin absorption (H); carcinogen category: 3; germ cell mutagen group: 3B

ENVIRONMENT
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. TLV only established for mixed isomers. See ICSCs 0451, 0600, 1519, 1686 and 1687.

ADDITIONAL INFORMATION

EC Classification
Symbol: T, N; R: 23/24/25-33-51/53; S: (1/2)-28-36/37-45-61; Note: C

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    See Also:
       Toxicological Abbreviations