ICSC 1438 - DISULFIRAM

DISULFIRAM	ICSC: 1438 (September 2002)
Tetraethylthiuramdisulfide 1,1'-Dithiobis(N,N-diethylthioformamide) bis-(N,N-Diethylthiocarbamoyl)disulfide TETD

CAS #: 97-77-8

EC Number: 202-607-8

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Finely dispersed particles form explosive mixtures in air.	NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Prevent build-up of electrostatic charges (e.g., by grounding).	Use water spray, powder, foam, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation		Use ventilation, local exhaust or breathing protection.
Skin		Protective gloves.	Rinse skin with plenty of water or shower.
Eyes		Wear safety spectacles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Confusion. Headache. Nausea. Vomiting.	Do not eat, drink, or smoke during work.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.	According to UN GHS Criteria Transportation UN Classification
STORAGE
Separated from strong oxidants.
PACKAGING

DISULFIRAM

ICSC: 1438

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance WHITE-TO-GREY POWDER WITH CHARACTERISTIC ODOUR. Physical dangers Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. Chemical dangers Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides and sulfur oxides. Reacts violently with strong oxidants. Attacks copper.	Formula: C₁₀H₂₀N₂S₄ / ((C₂H₅)₂NCS)₂S₂ Molecular mass: 269.6 Boiling point at 2.3kPa: 117°C Melting point: 71°C Density: 1.3 g/cm³ Solubility in water, g/100ml: 0.02 Octanol/water partition coefficient as log Pow: 3.9

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE-TO-GREY POWDER WITH CHARACTERISTIC ODOUR.

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.

Chemical dangers
Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides and sulfur oxides. Reacts violently with strong oxidants. Attacks copper.

Formula: C₁₀H₂₀N₂S₄ / ((C₂H₅)₂NCS)₂S₂
Molecular mass: 269.6
Boiling point at 2.3kPa: 117°C
Melting point: 71°C
Density: 1.3 g/cm³
Solubility in water, g/100ml: 0.02
Octanol/water partition coefficient as log Pow: 3.9

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of dust and by ingestion. Effects of short-term exposure	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the endocrine system, liver, nervous system and thyroid. This may result in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of dust and by ingestion.

Effects of short-term exposure

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the endocrine system, liver, nervous system and thyroid. This may result in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 2 mg/m³, as TWA; A4 (not classifiable as a human carcinogen). MAK: (inhalable fraction): 2 mg/m³; peak limitation category: II(8); sensitization of skin (SH); pregnancy risk group: D

ENVIRONMENT
The substance is toxic to aquatic organisms.

NOTES
In combination with alcohol the substance causes effects on cardiovascular and central nervous systems resulting in palpitation, hypotension and hyperventilation. The effects may be delayed. Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: Xn, N; R: 22-43-48/22-50/53; S: (2)-24-37-60-61

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    See Also:
       Toxicological Abbreviations
       Disulfiram (IARC Summary & Evaluation, Volume 12, 1976)