ICSC 1655 - ETHYLBIS(2-CHLOROETHYL)AMINE

ETHYLBIS(2-CHLOROETHYL)AMINE	ICSC: 1655 (April 2008)
HN1 Nitrogen Mustard Bis(2-chloroethyl)ethylamine 2-Chloro-N-(2-chloroethyl)-N-ethylethanamine 2-Chloro-N-(2-chloroethyl)-N-ethyl-ethanamine 2,2'-Dichloro-triethylamine

CAS #: 538-07-8

UN #: 2810

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Heating will cause rise in pressure with risk of bursting. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, alcohol-resistant foam, carbon dioxide, powder. In case of fire: keep drums, etc., cool by spraying with water.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sore throat. Burning sensation. Cough. Tremor. Incoordination. Convulsions. Laboured breathing. Shortness of breath. Wheezing. Symptoms may be delayed. See Notes.	Use closed system.	Half-upright position. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention.
Skin	MAY BE ABSORBED! Redness. Pain. Blisters. Symptoms may be delayed. Further see Inhalation.	Protective gloves. Protective clothing.	Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.
Eyes	VAPOUR WILL BE ABSORBED! Watering of the eyes. Redness. Pain. Spasms, photophobia and dilated pupils. Blurred vision. Severe deep burns. Loss of vision.	Wear safety goggles. Wear face shield or eye protection in combination with breathing protection.	Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Ingestion	Sore throat. Abdominal pain. Burning sensation in the throat and chest. Nausea. Vomiting. Diarrhoea. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention. See Notes.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable air tight containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. NEVER direct water jet on liquid.	According to UN GHS Criteria DANGER Fatal in contact with skin or if inhaled Causes skin irritation Causes serious eye damage May cause genetic defects May cause cancer Causes damage to nervous system and bone marrow May cause respiratory irritation Causes damage to the nervous system and the bone marrow through prolonged or repeated exposure Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: I
STORAGE
Keep in the dark. Separated from food and feedstuffs and metals. Keep in a well-ventilated room. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs.

ETHYLBIS(2-CHLOROETHYL)AMINE

ICSC: 1655

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR. Physical dangers Chemical dangers The substance polymerizes under the influence of heat and light. Attacks many metals. This produces flammable gas (hydrogen - see ICSC 0001).	Formula: C₆H₁₃Cl₂N / (ClCH₂CH₂)₂NC₂H₅ Molecular mass: 170.1 Decomposes at 194°C Melting point: -34°C Relative density (water = 1): 1.09 Solubility in water at 25°C: very poor Vapour pressure, kPa at 25°C: 0.03 Relative vapour density (air = 1): 5.9 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR.

Physical dangers

Chemical dangers
The substance polymerizes under the influence of heat and light. Attacks many metals. This produces flammable gas (hydrogen - see ICSC 0001).

Formula: C₆H₁₃Cl₂N / (ClCH₂CH₂)₂NC₂H₅
Molecular mass: 170.1
Decomposes at 194°C
Melting point: -34°C
Relative density (water = 1): 1.09
Solubility in water at 25°C: very poor
Vapour pressure, kPa at 25°C: 0.03
Relative vapour density (air = 1): 5.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol, through the skin and by ingestion. Serious local effects and systemic effects by all routes of exposure. Effects of short-term exposure Blistering agent. Lachrymation. The substance is severely irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and bone marrow. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.	Inhalation risk A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. Effects of long-term or repeated exposure The substance may have effects on the bone marrow and central nervous system. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. See Notes.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol, through the skin and by ingestion. Serious local effects and systemic effects by all routes of exposure.

Effects of short-term exposure
Blistering agent. Lachrymation. The substance is severely irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and bone marrow. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

Effects of long-term or repeated exposure
The substance may have effects on the bone marrow and central nervous system. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. See Notes.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT

NOTES
Do NOT take working clothes home. Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Because many of the effects resemble those of ionizing radiation, the term "radiomimetic" is frequently used.

NOTES

Do NOT take working clothes home.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Because many of the effects resemble those of ionizing radiation, the term "radiomimetic" is frequently used.

ADDITIONAL INFORMATION

EC Classification

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    See Also:
       Toxicological Abbreviations