IPCS INCHEM Home

Summary of Evaluations Performed by the
Joint FAO/WHO Expert Committee on Food Additives

IVERMECTIN
Chemical names: 5-O-DEMETHYL-22,23-DIHYDROAVERMECTIN-A1a; 5-O-DEMETHYL-25-DE(1-METHYLPROPYL)-22,23-DIHYDRO-25-(1-METHYLETHYL)AVERMECTIN-A1A; 22,23 DIHYDROAVERMECTIN B1b
Functional class: VETERINARY DRUG (ANTHELMINTHIC AGENT)
Latest evaluation: 2002
ADI: 0-0.001 mg/kg bw (1992)
Comments/MRLs: MRL (expressed as ivermectin B1a): Milk (cattle) 0.01 mg/kg. The MRLs recommended at the fortieth meeting (1992) were not reconsidered and were maintained.
Report: TRS 911-JECFA 58/10
Residues: FNP 41/14-JECFA 58/43
Tox monograph: FAS 31-JECFA 40/23 (1992)
Previous status: 2000, TRS 900-JECFA 54/7, FNP 41/13-JECFA 54/53, FAS 31-JECFA 40/23 (1992). 0-0.001 mg/kg bw (1992). MRL (TEMPORARY, EXPRESSED AS IVERMECTIN H2B1a): MILK (CATTLE) 0.01 mg/l. THE MRLs THAT WERE RECOMMENDED AT THE THIRTY-SIXTH MEETING (1990) AND THE FORTIETH MEETING (1992) WERE NOT RECONSIDERED AND WERE MAINTAINED. FU. TMRL
1992, TRS 832-JECFA 40/17, FNP 41/5-JECFA 40/37, FAS 31-JECFA 40/23. 0.001. MRLs (EXPRESSED AS 22,23-DIHYDROAVERMECTIN B1a): LIVER (CATTLE) 0.1; LIVER (OTHER SPECIES) 0.015; FAT (CATTLE) 0.04; FAT (OTHER SPECIES) 0.02. THE MRLs FOR SPECIES OTHER THAN CATTLE WERE ALLOCATED AT THE THIRTY-SIXTH MEETING (1990). FU. MRL
1990, TRS 799-JECFA 36/23, FNP 41/3-JECFA 36/45, FAS 27-JECFA 36/27. 0-0.0002. MRLs: LIVER (ALL SPECIES): 0.015; FAT (ALL SPECIES): 0.02. FU. MRL
 
1 Feb 03    




    See Also:
       Toxicological Abbreviations
       Ivermectin (WHO Food Additives Series 27)
       Ivermectin (WHO Food Additives Series 31)
       Ivermectin (PIM 292)