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Summary of Evaluations Performed by the
Joint FAO/WHO Expert Committee on Food Additives

LINCOMYCIN
Chemical names: METHYL 6,8-DIDEOXY-6-[[(1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL]AMINO-1-THIO-D-ERYTHRO-alpha-D-GALACTO-OCTOPYRANOSIDE, MONOHYDROCHLORIDE MONOHYDRATE; METHYL 6,8-DIDEOXY-6-(1-METHYL-trans-4-PROPYL-L-2-PYROLIDONE-CARBOXAMIDO)-1-THIO-D-ERYTHRO-alpha-D-GALACTO-OCTOPYRANOSIDE MONOHYDROCHLORIDE MONOHYDRATE
Synonyms: LINCOSIN; LINCOMYCIN HYDROCHLORIDE; PNU-10149A; ALBIOTIC®
Functional class: VETERINARY DRUG (ANTIMICROBIAL AGENT)
Latest evaluation: 2004
ADI: 0-0.03 mg/kg bw (2000)
Comments/MRLs: Previous MRLs (expressed as lincomycin) were maintained: Muscle (pigs and chickens): 0.2 mg/kg; liver (pigs and chickens): 0.5 mg/kg; kidney (pigs): 1.5 mg/kg; kidney (chickens): 0.5 mg/kg; fat (pigs and chickens): 0.1 mg/kg; milk (cattle): 0.15 mg/kg. MRLs for cattle tissues were considered at the present meeting but not recommended.
Report: TRS 925-JECFA 62/21
Residues: FNP 41/16-JECFA 62/41
Tox monograph: FAS 45-JECFA 54/3 (2000)
Previous status: 2002, TRS 911-JECFA 58/28, FNP 41/14-JECFA 58/45, FAS 45-JECFA 54/3 (2000). 0-0.03 mg/kg bw (2000). MRLS: MUSCLE (PIGS AND CHICKENS): 0.2 mg/kg; LIVER (PIGS AND CHICKENS): 0.5 mg/kg; KIDNEY (PIGS): 1.5 mg/kg; KIDNEY (CHICKENS): 0.5 mg/kg; FAT (PIGS AND CHICKENS): 0.1 mg/kg; MILK (CATTLE): 0.15 mg/kg. THE TEMPORARY MRLS FOR MUSCLE, LIVER, KIDNEY, AND FAT OF CATTLE RECOMMENDED AT THE FIFTY-FOURTH MEETING (2000) WERE NOT EXTENDED. A SEPARATE MRL OF 0.3 mg/KG FOR SKIN WITH ADHERING FAT IN PIGS WAS RECOMMENDED TO REFLECT THE HIGH CONCENTRATIONS FOUND IN THE SKIN OF THAT SPECIES. FOR CONSISTENCY, AN MRL OF 0.3 mg/kg FOR SKIN WITH ADHERING FAT IN CHICKENS WAS ALSO RECOMMENDED. THE MRLS FOR FAT RECOMMENDED AT THE FIFTY-FOURTH MEETING (2000) WERE MAINTAINED. FU. MRL
2000, TRS 900-JECFA 54/13, FNP 41/13-JECFA 54/43, FAS 45-JECFA 54/3. 0-0.03 mg/kg bw. MRLs (EXPRESSED AS LINCOMYCIN): MUSCLE AND FAT (PIGS): 0.1 mg/kg; LIVER (PIGS): 0.5 mg/kg; KIDNEY (PIGS): 1.5 mg/kg; MILK (CATTLE): 0.15 mg/kg. MRLs (TEMPORARY): MUSCLE AND FAT (CATTLE, SHEEP AND CHICKENS): 0.1 mg/kg; LIVER (CATTLE, SHEEP AND CHICKENS): 0.5 mg/kg; KIDNEY (CATTLE, SHEEP AND CHICKENS): 1.5 mg/kg. FU. MRL/TMRL
 
23 Apr 05    





    See Also:
       Toxicological Abbreviations
       Lincomycin (WHO Food Additives Series 45)