| MOXIDECTIN | |
| Chemical names: | SPIRO[11,15-METHANO-2H,13H,17H-FURO[4,3,2-PQ][2,6]-BENZODIOXACYCLO-OCTADECIN-13,2'[2H]PYRAN-17-ONE]-6'-[1,3-DIMETHYL-1-BUTENYL]-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b- DIHYDRO-4'-[METHOXYIMINO]-5',6,6,19-TETRAMETHYL-[6R-2aE,4E,4'E,5'S*,6R*,6'S*(E),8E, 11R* 13R*,15S*,17aR*,20R*,20aR*,20bS*]]- | Functional class: | VETERINARY DRUG (ANTHELMINTHIC AGENT) | Latest evaluation: | 1998 | ADI: | 0-0.002 mg/kg bw (1995) | Comments/MRLs: | MRLs (expressed as parent drug, in mg/kg): Muscle (cattle and deer): 0.02; Muscle (sheep): 0.05; Liver (cattle, sheep and deer): 0.1; Kidney (cattle, sheep and deer): 0.05; Fat (cattle, sheep and deer): 0.5. All MRLs were recommended at the forty-fifth meeting (1995), except the value for sheep muscle, which was recommended at the forty-seventh meeting (1996). At the forty-fifth meeting the Committee noted the very high concentrations and great variation in the level of residues at the injection site in cattle over a 49-day period after dosing. Final MRLs for sheep were recommended at the fifty-first meeting (1998). | Report: | TRS 888-JECFA 50/19 | Residues: | FNP 41/11-JECFA 50/79 | Tox monograph: | FAS 36-JECFA 45/27 (1995) | Previous status: | 1997, TRS 879-JECFA 48/6, FNP 41/10-JECFA 48/71, FAS 36-JECFA 45/27 (1995). 0-0.002 (1995). MRLs (EXPRESSED AS PARENT DRUG): MUSCLE (CATTLE): 0.02; MUSCLE (SHEEP): 0.05; LIVER (CATTLE AND SHEEP): 0.1; KIDNEY (CATTLE AND SHEEP): 0.05; FAT (CATTLE AND SHEEP): 0.5. TEMPORARY MRLs (EXPRESSED AS PARENT DRUG): MUSCLE (DEER): 0.02; LIVER (DEER): 0.1; KIDNEY (DEER): 0.05; FAT (DEER): 0.5. AT THE 45TH MEETING THE COMMITTEE NOTED THE VERY HIGH CONCENTRATIONS AND GREAT VARIATION IN THE LEVEL OF RESIDUES AT THE INJECTION SITE IN CATTLE OVER A 49-DAY PERIOD AFTER DOSING. ALL MRLs WERE RECOMMENDED AT THE 45TH MEETING (1995) EXCEPT FOR SHEEP MUSCLE, WHICH WAS RECOMMENDED AT THE 47TH MEETING (1996); THE MRL FOR CATTLE MUSCLE WAS CONFIRMED AT THE 48TH MEETING (1997). FU. MRL/TMRL (DEER)
1996, TRS 876-JECFA 47/20, FNP 41/9-JECFA 47/71, FAS 36-JECFA 45/27 (1995), 0.002 (1995), MRLs, EXPRESSED AS PARENT DRUG; EXCEPT FOR SHEEP MUSCLE, ALL MRLs WERE ESTABLISHED IN 1995: MUSCLE (CATTLE): 0.02; MUSCLE (SHEEP): 0.05; LIVER (CATTLE AND SHEEP): 0.1; KIDNEY (CATTLE AND SHEEP): 0.05; FAT (CATTLE AND SHEEP): 0.5. TEMPORARY MRLs, EXPRESSED AS PARENT DRUG (DEER): MUSCLE: 0.02; LIVER: 0.1; KIDNEY: 0.05; FAT: 0.05. AT THE 45TH MEETING THE COMMITTEE NOTED THE VERY HIGH CONCENTRATIONS AND GREAT VARIATION IN THE LEVEL OF RESIDUES AT THE INJECTION SITE IN CATTLE OVER A 49-DAY PERIOD AFTER DOSING. FU. MRL/TMRL 1995, TRS 864-JECFA 45/15, FNP 41/8-JECFA 45/107, FAS 36-JECFA 45/27. 0-0.002. MRLs, EXPRESSED AS PARENT DRUG (CATTLE AND SHEEP): MUSCLE: 0.02; LIVER: 0.1; KIDNEY: 0.05; FAT: 0.5; TEMPORARY MRLs, EXPRESSED AS PARENT DRUG (DEER): MUSCLE: 0.02; LIVER: 0.1; KIDNEY: 0.05; FAT: 0.5. FU. MRL/TMRL |
| 12 Nov 01 | |
See Also:
Toxicological Abbreviations
Moxidectin (WHO Food Additives Series 36)