JECFA Evaluations-CADMIUM-

Summary of Evaluations Performed by the
Joint FAO/WHO Expert Committee on Food Additives

CADMIUM
Functional class:	CONTAMINANT
Latest evaluation:	2005
Tolerable Intake:	PTWI 0.007 mg/kg bw
Comments:	The PTWI of 0.007 mg/kg bw that was established at the thirty-third meeting (1988) was not re-evaluated and was maintained at the sixty-fourth meeting (2005). The Committee evaluated the impact of different maximum levels on the overall intake of cadmium and concluded that the effect would be very small. At the proposed Codex maximum levels, mean intake of cadmium would be reduced by approximately 1% of the PTWI. The imposition of maximum levels one level lower would result in potential reductions in intake of cadmium of no more than 6% (wheat, potatoes) of the PTWI. At the proposed Codex maximum levels, no more than 9% of a commodity would be violative (oysters). Maximum levels one level below those proposed would result in approximately 25% of molluscs, potatoes, and other vegetables being violative.
Report:	TRS 930-JECFA 64/26
Tox monograph:	FAS for JECFA 64 in press
Previous status:	2003, TRS 922-JECFA 61/127, FAS 52-JECFA 61/505. THE PTWI OF 0.007 MG/KG BW THAT WAS ESTABLISHED AT THE THIRTY-THIRD MEETING (1988) WAS MAINTAINED AT THE SIXTY-FIRST MEETING (2003). 2000, TRS 901-JECFA 55/61, FAS 46-JECFA 55/247. THE PTWI OF 0.007 mg/kg bw THAT WAS ESTABLISHED AT THE THIRTY-THIRD MEETING (1988) WAS MAINTAINED AT THE FIFTY-FIFTH MEETING. RANGES OF PREDICTED DIETARY INTAKES THAT MAY BE ASSOCIATED WITH EXCESS PREVALENCE OF RENAL TUBULAR DYSFUNCTION WERE ESTIMATED BASED ON THREE DIFFERENT SCENARIOS. 1993, TRS 837-JECFA 41/28, FAS 24-JECFA 33/163 (1988). PTWI 0.007 mg/kg bw 1988, TRS 776-JECFA 33/28, FAS 24-JECFA 33/163. PTWI 0.007 mg/kg bw 1972, TRS 505-JECFA 16/20, FAS 4-JECFA 16/51. PTWI 0.0067-0.0083 mg/kg bw

31 Jan 06