| CARAZOLOL | |
| Chemical names: | 4-(2-HYDROXY-3-ISOPROPYL-AMINO-PROPOXY)-CARBAZOLE, 1-(CARBAZOLE-4-YL-OXY)-2- HYDROXY-3-ISOPROPYLAMINO-PROPANE, 1-(4-CARBAZOLYLOXY)-3-(ISOPROPYLAMINO)-2- PROPANOL | Functional class: | VETERINARY DRUG (beta-ADRENOCEPTOR BLOCKING AGENT) | Latest evaluation: | 1999 | ADI: | 0-0.0001 mg/kg bw (1994) | Comments: | The Committee established an acute reference dose (RfD) of 0.0001 mg/kg bw for carazolol at the fifty-second meeting (1999), at which time it was noted that residues of carazolol at the injection site 2 h after treatment could result in an intake that exceeds the acute RfD. Therefore, unless appropriate measures can be taken to ensure that the concentrations of residues at the injection site do not exceed the acute RfD, use of carazolol during the transport of animals to slaughter is not consistent with safe use of the drug. | Comments/MRLs: | The MRLs recommended at the forty-third meeting (1994) were not revised. | Report: | TRS 893-JECFA 52/13 | Residues: | FNP 41/12-JECFA 52/137 | Tox monograph: | FAS 43-JECFA 52/3 | Previous status: | 1994, TRS 855-JECFA 43/5, FNP 41/7-JECFA 43/9, FAS 34-JECFA 43/3. 0-0.0001. MRLs (EXPRESSED AS PARENT DRUG): MUSCLE AND FAT/SKIN (PIGS): 0.005; LIVER AND KIDNEY (PIGS): 0.025. FU. MRL
1991, TRS 815-JECFA 38/7, FNP 41/4-JECFA 38/23, FAS 29-JECFA 38/3. 0-0.0001 (TEMPORARY). MRLs (TEMPORARY): MUSCLE AND FAT (CATTLE AND PIGS): 0.005; LIVER AND KIDNEY (CATTLE AND PIGS): 0.03. TE. TMRL |
| 12 Mar 03 | |
See Also:
Toxicological Abbreviations
Carazolol (WHO Food Additives Series 29)
Carazolol (WHO Food Additives Series 34)